HORDB

General Information

ID: hor006400
Uniprot ID: P12272
Protein name: Osteostatin
Gene name: PTHLH
Organism: Homo sapiens (Human)
Family: Parathyroid hormone family
Source: Human
Expression: Ubiquitous. Also expressed in the mammary gland.
Disease: Diseases associated with PTHLH include Brachydactyly, Type E2 and Brachydactyly, Type E1.
Comments: NA
Taxonomy: Homo (genus), Homininae (subfamily), Hominidae (family), Hominoidea (superfamily), Catarrhini (parvorder), Simiiformes (infraorder), Haplorrhini (suborder), Primates (order), Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity; GO:0005515 protein binding; GO:0051428 peptide hormone receptor binding
GO BP: GO:0001501 skeletal system development; GO:0002076 osteoblast development; GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway; GO:0007267 cell-cell signaling; GO:0007565 female pregnancy; GO:0008284 positive regulation of cell population proliferation; GO:0008285 negative regulation of cell population proliferation; GO:0008544 epidermis development; GO:0010468 regulation of gene expression; GO:0030282 bone mineralization; GO:0032330 regulation of chondrocyte differentiation; GO:0032331 negative regulation of chondrocyte differentiation; GO:0046058 cAMP metabolic process; GO:0061182 negative regulation of chondrocyte development
GO CC: GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0005634 nucleus; GO:0005654 nucleoplasm; GO:0005737 cytoplasm; GO:0005794 Golgi apparatus; GO:0005829 cytosol

Sequence Information

Sequence: TRSAWLDSGVTGSGLEGDHLSDTSTTSLELDSR
Length: 33(143-175)
Propeptide: MQRRLVQQWSVAVFLLSYAVPSCGRSVEGLSRRLKRAVSEHQLLHDKGKSIQDLRRRFFLHHLIAEIHTAEIRATSEVSPNSKPSPNTKNHPVRFGSDDEGRYLTQETNKVETYKEQPLKTPGKKKKGKPGKRKEQEKKKRRTRSAWLDSGVTGSGLEGDHLSDTSTTSLELDSRRH
Signal peptide: MQRRLVQQWSVAVFLLSYAVPSCG
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Activity

Function: Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interaction
Mechanism: NA
Cross BBB: NA
Target: PTH1R
Target Unid: Q03431
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure

Disulfide bond: NA
Structure ID: AF-P12272-F1(AlphaFold_DB_ID)

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor006400_AF2.pdb

hor006400_ESM.pdb

Physical Information

Mass:	402257	Formula:	C142H228N42O58
Absent amino acids:	CFIKMNPQY	Common amino acids:	S
pI:	4.04	Basic residues:	3
Polar residues:	16	Hydrophobic residues:	8
Hydrophobicity:	-60	Boman Index:	-8311
Half-Life:	7.2 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	70.91
Instability Index:	3456.06	Extinction Coefficient cystines:	5500
Absorbance 280nm:	171.88

Literature

PubMed ID: 3616618
Title: A parathyroid hormone-related protein implicated in malignant hypercalcemia: cloning and expression.
PubMed ID: 2829195
Title: Identification of a cDNA encoding a parathyroid hormone-like peptide from a human tumor associated with humoral hypercalcemia of malignancy.
PubMed ID: 2708388
Title: Characteriz
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